g 10 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8328	STING agonist-1	G10	Virus Protease , STING
	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.		Virus Protease , STING
T31993	Grayanotoxin II	G-II,Deacetylanhydroandromedotoxin,delta(sup 10 (18))-Andromedenol
	Grayanotoxins are a group of closely related neurotoxins named after Leucothoe grayana. Extract from leaves of Ericaceae.
T4839	Ac-Ala-OH	N-Acetylalanine,N-Acetyl-L-alanine	Others , Endogenous Metabolite
	Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding pro...		Others , Endogenous Metabolite
T8752	BAR 501 impurity		GPCR19
	BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act...		GPCR19
T38293	4-CPPC		Others
	4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concen...		Others
T37816	SB 243213
	SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o...
T13817	Phen-DC3		Others
	Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases (IC50s of 65±6 and 50±10 nM, respectively).		Others
T27970	Mabuterol free base	Mabuterol,PB 868Cl	Others
	Mabuterol is a selective agonist of β2 adrenoreceptor with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6)...		Others
T82258	GRL018-21
	GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].
T13817L	Phen-DC3 Trifluoromethanesulfonate	Phen-DC3 Triflate	Others
	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).		Others
T36968	ARN-21934		Topoisomerase
	ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...		Topoisomerase
T81900	LVGRQLEEFL (mouse) (TFA)
	G* peptide, also known as LVGRQLEEFL (mouse) TFA, is a segment corresponding to amino acids 113 to 122 ([113,122] apoJ) of apolipoprotein J. This compound possesses both anti-inflammatory and anti-atherogenic qualities. ...
T81901	LVGRQLEEFL (mouse)
	G* Peptide, also denoted as LVGRQLEEFL (mouse), represents the amino acid sequence 113 to 122 ([113,122] apoJ) found in apolipoprotein J. This compound displays both anti-inflammatory and anti-atherogenic characteristics...
T83666	Kisspeptin-10 (zebrafish) TFA	Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10
	Kisspeptin-10, a neuropeptide present in the brains, ovaries, and testes of zebrafish, plays a critical role in gonadal development and steroid expression. At a concentration of 10 ng/ml, it enhances the mRNA levels for ...
T81311	RASP-IN-1
	RASP-IN-1 (Compound A), a lipophilic compound, serves as an inhibitor for macular degeneration and exhibits biological activity within the rabbit retina. In a mouse model [1], the administration of 14 C-RASP-IN-1 (10 mg/...
T79134	FEN1-IN-6		FLAP
	FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally targets the related endonuclease xeroderma pigmentosum G (XPG) wit...		FLAP
TN6674	Cyclo-(Pro-Gly)	Cyclo(Pro-Gly)
	Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the con...
T36719	D-NAME (hydrochloride)
	N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as...
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-...
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) la...